Analysis of metabolic systems

Please input your model for analysing metabolic system

Example 1:
Example 2:


1. Metabolites
 Names
 Initial values
 Ordinary differential equations

2. Enzymes

 Parameters
 Values

3. StartTime

4. EndTime
5. Interval

Please select the number of metabolites and enzymes


Analysis: Results


Dynamic behaviours of metabolite concentrations are observed in response to a change of considered enzymes. Analysis permits the elucidation of dynamic characteristics of a metabolic system by setting a parameter value that refers to enzyme activity.
Sensitivity analysis is typically used for observing robustness and uncertainty in the metabolic behaviours of a mathematical model.
Logarithmic gain is the relative sensitivity defined as the change in a dependent variable (metabolite concentration) in response to an infinitesimal change in an independent variable (enzyme activity).
The BR indicator is defined as the product of dynamic logarithmic gain and metabolite concentration and is used in the quantitative determination of bottleneck enzymes. For variable parameters such as enzyme activities in the model, the BR indicator can identify the effects of metabolic perturbation by quantitative comparison of metabolite concentrations, which dynamically change in response to parameter changes.